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この英文の意味を教えてくださいm(__)m

sekken19720704の回答

回答No.1

強化されたNrf2の活性が悪化するのインスリン抵抗性は、脂肪組織における脂質の蓄積を阻害し、レプチン欠損マウスにおける脂肪肝を増加させる。 抽象的な 研究では、本明細書核因子erythoid 2に関連する因子肝臓脂肪症、インスリン抵抗性、肥満症、および2型糖尿病の病因における2 ( Nrf2の)の役割を決定した。 LEP (OB / OB) - KEAP1ノックダウンNrf2の活性を増加させた( KD )マウスは、生成された。肥満や2型糖尿病のマーカーはC57BL/6J 、 KEAP1 -KD 、 LEP (OB / OB) 、及びLEP (OB / OB) - KEAP1 -KDマウスで測定した。 LEP (OB / OB ) KEAP1 -KDマウスは、より少ない脂質蓄積、小さい脂肪細胞を示し、食物摂取を減少し、脂質合成遺伝子発現を減少させた。強化されたNrf2の活性が損なわれたインスリンシグナル伝達、グルコースチャレンジに対する応答で長時間高血糖、及びLEPで誘発インスリン抵抗性(OB / OB)背景。肝臓におけるNrf2の拡張脂肪肝と増加脂質沈着。次に、 C57BL/6JとKEAP1 -KDマウスは、高脂肪食( HFD )はKEAP1とNrf2の影響かどうかHFD誘発性肥満を判断するために送り込まれた。白色脂肪組織においてHFD誘発される肥満および脂質の蓄積がKEAP1 -KDマウスにおいて減少した。 KEAP1 -KDまたはスルフォラファン経由Nrf2の活性化は、ホルモン誘発性の分化を抑制し、ペルオキシソーム増殖因子活性化受容体-γ 、 CCAAT /エンハンサー結合タンパク質αを減少し、マウス胚性線維芽細胞における脂肪酸結合タンパク質4の発現。恒常Nrf2の活性化は、白色脂肪組織における脂質の蓄積を抑制し脂肪生成、誘発インスリン抵抗性や耐糖能異常、及びLEPの増加脂肪肝(OB / OB )マウスを抑制した。

kuzuyu_200
質問者

補足

すみません。せっかく回答していただいて申し訳ないのですが、質問に書いたとおり、翻訳ソフトでの訳では意味が分からなかったので、今回投稿いたしました。

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