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Understanding the Role of Interstitial Cells of Cajal in Gastrointestinal Motility Disorders
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- litsa1234
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以下に参考訳を載せます。 (1)Acknowledgment of the importance of interstitial cells of Cajal(ICC) for the integrity of the motor function of the gastrointestinal(GI) tract prompted interest in the fate of ICC in gut motor disorders. Damage to ICC and/or reduction of its population has been described in almost every GI motility disorder from the esophagus to the rectum. 胃腸管の運動機能を保全する為にはカハールの間質細胞（以後ICCと称す）が重要であるということが認められたので、次に腸の運動不全におけるICCの成行きに関心が向けられたのである。ICCへの損傷及び、又はICCの総数の減少はほとんど全て食道から直腸にかけての胃腸運動機能障害の中で記述されてきたのである。 (2)The degree of disruption of the ICC network is a function of the distance from the obstruction and it is reversible after the obstruction is removed, highlighting a remarkable degree of plasticity. ICC網の中断の度合いは閉塞部分からの距離の関数であり、閉塞部分が取り除かれた後では中断の度合いは反転し、ICC網の自動結合能力の度合いが目覚ましく高まることを示している。 (3)This intrinsic ICC plasticity is important because it opens a window for recovery of the ICC phenotype and function if the underlying insult is addressed, although it remains unclear whether human ICC are as susceptible to distension as they are in smaller species. このICCに本来備わっている自動結合能力というものは、もしも潜在的な損傷に近づいた場合、人間のICCが小動物のICCのように膨張に弱いかどうか分からないとしても、ICCの表現型や機能を回復するための窓を開いてくれるので、大事なのである。 (4)Nevertheless, one should conclude that there is no interaction between nerves and ICC related to survival as demonstrated for intramuscular ICC in the stomach and afferent vagal nerves. It is currently unknown whether ICC and nerves, in diseased states, simultaneously are injured by the same mechanism or if injury to ICC can be secondary to the loss of neural structures. にもかかわらず、以上示されたように胃の中の筋肉内ICCが生存するために関連している神経とICCというものと、求心性の迷走神経というものは相互作用しないというのが妥当な結論である。ICCと神経が疾患状態において同時に同じメカニズムで損傷するのかどうか、またICCへの損傷のほうが神経構造の損傷よりも二次的でありうるのかということについては今のところ不明なのである。 (5)but it is unclear if ICC have access to neuronally produced stem cell factor. しかし、ICCが神経細胞内に作られた幹細胞因子に接触しているかどうかは不明である。 (6)Damage to neural structures in Crohn's disease or ulcerative colitis is to a large part mediated by the inflammatory infiltrate, クローン病や潰瘍性大腸炎の神経系への損傷は大部分、炎症性浸潤によって媒介される。 (7)By contrast, different types of macrophages seem to be cytoprotective to ICC, as in a mouse model of diabetic gastroparesis, likely owing to up-regulation of heme oxygenase-1(HO-1) and subsequent reduction in oxidative stress. 対照的に、異なるタイプのマクロファジ（貪食細胞）はICCに細胞保護的に働くようである。例えば糖尿病性胃アトニーの検体マウスの場合がそうである。その理由はおそらく、ヘムオキシゲナーゼ-1の増加調節が先ず起こり、そのあとに酸化ストレスが減少するということなのであろう。 以上、参考になれば幸いです。
noname#202629
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