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Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking transcription in the nucleus to translation in the cytoplasm. Although important components of the mRNA export machinery are well characterized, such as transcription-export complexes TREX and TREX-2, recent work has shown that, in some instances, mammalian mRNA export can be selective and can regulate crucial biological processes such as DNA repair, gene expression, maintenance of pluripotency, haematopoiesis, proliferation and cell survival. Such findings show that mRNA export is an unexpected, yet potentially important, mechanism for the control of gene expression and of the mammalian transcriptome.

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mRNAの核外移行は遺伝子発現の調節における非常に重要なステップであり、核転写と細胞質における移行とを結びつけるものである。mRNA移行機構の重要な構成要素が転写移行によるTREX複合体とTREX-2複合体のように明確に特性化されているのだが、ある場合では、哺乳類のmRNA核外移行は選択的であり、かつ、DNAの修復、遺伝子発現、多能性の維持、造血、増殖、細胞生存のような非常に重要な生物学的プロセスを制御していると最近の研究では報告されている。ここでの発見は、mRNA移行が突発的に発生し、潜在的重要性を持ちながら、遺伝子発現や哺乳類のトランスクリプトームの制御を行うメカニズムであることを示すものである。

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ありがとうございます! なんとか自分で和訳したのですが、自信がなかったので、助かりました!

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