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Examples of selectivity of mRNA export Evidence is accumulating that mRNA export in mam mals can be selective, although it remains possible that a large proportion of mRNAs are exported by bulk export pathways. Diverse biological processes, including throu DNA repair, maintenance of pluripotency, gene expres- and ion, stress responses, cell proliferation, cell survival and haematopoiesis 4-22 can be regulated by selective mRNA export and, in most of these cases, although not all, selectivity is mediated by components of the TREx and TREX-2 complexes.

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mRNAの大部分は、多量の核外遊出となる経路を経て遊出しているらしいとの可能性を残しているものの、哺乳類におけるmRNA核外遊出は、選択性を持っているという事実が多数集まっている。多様な生物学的なプロセス、例えば、DNA修復、多様性の維持、遺伝子発現、対ストレス反応、細胞増殖、細胞生存等は選択性のmRNA核外遊出により制御されており、これらのケースの全てではないものの多くは、TREXとTREX-2複合体の構造体によって選択的に仲介されているのである。

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