シンデカン4の変異による影響
- シンデカン4のシトプラズム末端の変異により、PIP2への親和性が低下するか、postsynaptic density 95、disk large、zona occuludens-1（PDZ）に依存した結合が異常になると（PDZ-）、内皮細胞ではFGF2に特異的な劣性影響が生じ、移動および増殖能力の低下、チューブ形成能力の障害が見られました。
- シンデカン4のシトプラズム末端の変異により、PIP2への親和性が低下するか、postsynaptic density 95、disk large、zona occuludens-1（PDZ）への依存性結合が異常になると（PDZ-）、内皮細胞のFGF2に対する反応が変化し、移動や増殖能力の低下、チューブ形成能力の障害が起こりました。
- シンデカン4のシトプラズム末端の変異により、PIP2への親和性が低下するか、postsynaptic density 95、disk large、zona occuludens-1（PDZ）への依存性結合が異常になると（PDZ-）、内皮細胞のFGF2への感受性に変化が生じ、移動や増殖能力の低下、チューブ形成能力の障害が観察されました。
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Mutations in the cytoplasmic tail of syndecan-4 that either reduced its affinity to PIP2(PIP2-) or disrupted its postsynaptic density 95,disk large,zona occuludens-1(PDZ)-dependent binding(PDZ-) produced a FGF2-specific dominant negative phenotype in endothelial cells as evidenced by the marked decline of their migration and proliferation rates and the impairment of thier capacity to form tubes ほんとにわけわからなくって困ってます。和訳お願いします。 syndecan-4:シンデカン４ PIP2:PIP2 そのままです
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和訳お願いします、とのことなので、 大雑把に和訳してみました。いかがでしょう？ PIP2に対するその親和性を低減させる（PIP2-）か、 または、そのPDZ（postsynaptic density 95/disk large/zona occuludens-1）依存性結合を壊す（PDZ-）、シンデカン４の細胞質尾部における変異によって、内皮細胞においてFGF2-特異的なドミナントネガティブ性の表現型が生じた。この表現型は、それらの移動速度および増殖速度の著しい低下、ならびに管を形成するそれらの能力の欠損によって示される。 PDZは、神経系タンパク質に多く見られるドメインだそうで、代表的に、Postsynaptic density 95、Disk large、Zona occuludens-1というタンパク質によく見られるために、それらの頭文字をとってPDZと名づけられたようですね。 という訳で、（postsynaptic density 95/disk large/zona occuludens-1）はスペルのままで残しました。
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The narrative structure of many images in the titles of two articles:"Yemen Opens the Door to Progress:American scientists visit this Arabian land at the invitation of its king to improve the health of hispeople"(1952)"and "Progress and Pageantry in Changing Nigeria:Bulldozers and penicillin,science and democracy come to grips with colorfulage-old customs in Britain's largest coliny"(1956).
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本当にありがとうございます。僕はアホなんでPostsynaptic density 95、Disk large、Zona occuludens-1がＰＤＺの略なんて思いもしませんでした。