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The research offers a clear warning that efforts to eradicate malaria should be accelerated, says Sanjeev Krishna from St George's University of London, who studies the biochemical origins of artemisinin resistance. He says that he expected resistance to occur eventually — but not as soon as this. "I thought we would have had longer," he says. More intensive drug-development programmes are needed, he adds, to find new drugs based on artemisinin, as well as alternatives. An eradication programme combining continued treatment and use of mosquito nets is under way in this area of Cambodia, Day says. "It's going to need considerable political willpower, scientific research and financial resources to achieve," he cautions. But without it, there is a danger that the resistant parasite could reach the world's malaria heartland — Africa. "That," says Day, "would be a major disaster." よろしくお願いします^^;

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この調査は、マラリア根絶の為一層の努力をすべきだという明瞭な警告を提示しているのです。とアルテミシニン耐性の生化学起源を研究しているロンドン、セント・ジョージス大学のサンジーヴ・クリシュナは言います。 彼によると、これほど早くではなくとも、菌の耐性が最終的に起ることは予想されていたとのことです。 「もうすこし時間がかかるものと思っていたのです。」と。 代替療法もあわせた、アルテミシニンベースの新薬を発見する更なる徹底的医薬品開発プログラムが急務なのですと彼は付け加えます。 継続的治療と蚊帳の使用を併用した根絶プログラムが、カンボジアのこの地域で進行中です、とデイは述べています。 「成功させるにはかなりの政治的意志(※1)、科学的研究、そして財源が必要となるでしょう。」と彼は注意を促します。 しかしそれがなければ、耐性をもった原虫が世界におけるマラリア中心地、つまりアフリカに及ぶ危険性があるのです。 「それは」「最悪の事態となります。」とデイは言います。 ※1:ここでは強い政治的サポートという意味かと存じます。

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    Malaria parasites in Cambodia are becoming increasingly resistant to the drug hailed as the world's best chance to eradicate the disease. Artemisinin-based drugs are currently the best weapon against malaria, a disease which kills around a million people every year and is spread by mosquitoes carrying malaria parasites such as Plasmodium falciparum. These parasites have already developed resistance to drugs such as chloroquine and sulfadoxine-pyrimethamine, once the front line against the disease, so hopes have been pinned on artemisinin-combination therapies (ACTs). The parasites have become far less easy to treat with ACTs, however, in the Cambodian city of Pailin, close to the country's western border with Thailand. The finding was made by researchers from the Wellcome Trust–Mahidol University Oxford Tropical Medicine Research Programme, based in Bangkok, Thailand. In particular, the parasites are becoming more resistant to a combined therapy of artesunate, derived from artemisinin, and mefloquine, a quinine analogue. This combination is used to treat malaria worldwide. Rumours about artemisinin resistance in Cambodia have been circulating for a number of years, and a relatively small study by Harald Noedl at the Medical University of Vienna and his colleagues, published late last year, suggested that resistance was emerging. よろしくお願いしますm(。・ω・。)m

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