英文の和訳をお願いします。
The body is protected against attack from bacteria and viruses by the immune system.White blood cells, especially those known as T-cells, play a central role in this fight against harmful invaders. In rare cases, however, the natural action of the immune system can cause problems. One such case is organ transplantation, in which the immune system attacks the new organ and causes the body to reject it.
In order to suppress this rejection, several types of immunosuppressant drugs have been used. However, the discovery of cyclosporine in 1976 has been unparalleled by any other breakthrough in the long history of tissuen and organ transplantation. This medication has had a revolutionary impact, enabling the graft survival rate of renal transplants to increase from 40 to 90 percent. It is safe to say that the drug has moved transplantation from the realm of miracle into routine therapy.
Cyclosporine prevents organ rejection by blocking certain immune pathways that are activated when the body detects foreign cells. At the same time, however, this medication indiscriminately blocks other cellular signal pathways, causing serious side effects such as high blood pressure and high cholesterol. These conditions can cause cardiovascular disease and kidney toxicity that may ultimately lead to organ failures. In addition, long-term cyclosporine use damages the body's immune system itself, preventing it from fighting off infections following transplant.
Now, research is being done to develop drugs that can prevent rejection as effectively as cyclosporine, while avoiding its harmful side effects. One such drug is belatacept. This promising new immunosuppressant prevents T-cell activation by selectively blocking one of the two signals T-cells need in order to become fully activated and to initiate an immune response against a transplanted organ. By selectively blocking this co-stimulatory signal, the drug allows the body to continue fighting infections, while preventing organ rejection. Though further study and testing must be done before the drug can be recommended as a routine replacement for cyclosporine, belatacept could brighten the futures of many who suffer from chronic renal disease and other types of organ failure.
お礼
素晴らしいです。その通りだと思います。感謝感激です。ありがとうございました。またお助け下さい。